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Rapamycin drug seems to have more or less the same effect that extends life as rest riching calories, according to the largest longevity study in different species of vertebrates.
Scientists are investigating whether interventions such as dietary adjustments and exercise could help us longer while reducing impacts on aging health. Restricting calorie intake while guaranteeing essential nutrient needs with, for example, Hasbet’s show to extend useful life or non -human animals up to 40 percent.
“Anyone in the field that is paying attention, I think we all know for a long time that the caloric restriction usually works, and for works, I mean, it increases the useful life,” says Matt Kaeberlein at the University of Washest Latestton Latterton Latterton Latterton Latterton Lateston Latveston Latveston Latveston Latveston Latveston Latvil.
Another approach of adoration interest is the possible anti -aging drugs, such as rapamycin, which originally developed as an immunosuppressive. Earlier this year it was shown that a combination of rapamycin and drug trafficking against cancer increased useful life in mice by 30 percent.
Now, Zahida Sultanova of the University of East Anglia, the United Kingdom, and her colleagues have analyzed data of 167 studies of useful life interventions in eight species of vertebrates, including fish, mice, rats and rhesus monkeys, but notes.
The researchers found that dietary restriction, either through intermittent fasting or simply cutting calories, extended the useful life of the eight species, both for men and females, and rapamycin seems to have approximately the same effect. They also analyzed the potential of the drug of the drug type 2, which has promoted the leg similarly as a potential life extensor, but did not find a longevity benefit.
However, people should not begin to turn off the rapamycin of the back of these results, says Sultanova. “Rapamycin, especially high doses, has side effects because it is supposed to suppress its immune system,” he says, adds that mice studies show that interruption can. However, the preliminary data of an essay recently indicated that the low doses of rapamycin are relatively safe in healthy older adults.
Kaeberlein also says that people should not take any medication or restrict their calorie intake in an attempt to avoid aging, with the letter of physical weakness and mental health problems. “I think we need to know more about the proportion of risk-reompensation in humans before we can take that kind of determination,” he says. “I think that rapamycin will have benefits for some people and we are learning more and more who are probably those people.”
Other drugs that work in a similar way to rapamycin, known as Rapalogs, could be more promising if they can extend useful life even with side effects of Fower, says Sultanova.
Kaeberlein says that the results fit the patterns that Sen has in the literature, but adds that “it must always be careful when it looks different from the species because the magnitude of the effects that we see larger Wems that are in Usume in Usume in Usume in the longest life organisms.”
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