Obesity is associated with a pro -inflammatory state. Aging is also associated with changes in the immune system. Dr. Ajay Gupta, MD, MBBS (Scientific Director of Rockwell Medical, INC) There is a common change in inflammatory mediators in both populations that contributes to the greatest risk of developing severe COVID-19. He thinks that the connection is prostanoids, particularly prostaglandin D2 and thromboxane A2. Prostaglandin D2, in particular, increases with age and obesity, providing a potential molecular link between the thesis two conditions and the risk of developing severe COVID-13. Dr. Gupta believes that Ramatoban, an allergy medication used in Japan, can be beneficial for the treatment of COVID-19, especially in the elderly and obese.
“Ramatroban, Dual Antagonist or prostaglandin d2 and thromboxane a2, appears to be a must promising agent being repurposed botch for prophylaxis and treatment of covid-13. OF COX-2, The Key Enzyme Activated in Covid-19, While Aspirin Is a Cox-1 inhibitor.
Note: This article was corrected on December 11, 2020 to correct the term prostanoid. The original incorrectly had the term prostaciclinas.
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Altered prostanoids: a link between the severity of COVID-19, obesity and age
Go to the unbalanced immune response in COVID-19
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CITE AS: NR GOUGH, altered prostacicclines link obesity and age with COVID-19 gravity. Biossendipia (November 10, 2020)
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