Biohackers live through the mantra, “proof, do not guess”: find out how well their cells and organists are getting old, so that it knows that changes in lifestyle and supplements to take a longer and more healthy life.
Some tests analyze intestinal bacteria or blood proteins to predict healthy aging, while others focus on changes in DNA.
Recently one of these DNA kits cools, a Tallly Health, based in Try-Manhattan, sells a swab test of $ 249 that estimates the biological age and makes recommendations to help improve the results.
“Many people who have written to us or have spoken that they have used as an inspiration to make a reason, GUV Johnson, head of scientific affairs and education at Tally Health told me.
The test, called Tallyage, was launched in 2023. A new study reviewed by pairs of the Tally Health team confirmed that dozens of diseases and health conditions, such as pulmonary fibrosis, non -alcoholic fatty liver disease, cancers and tumors, increase the probability of a significantly higher timbre.
“We are trying to learn more about what types of things they go down or increase the count,” said Johnson.
How the count works
Almost all cells in our body contain the same basic set of DNA.
The count measures DNA methylation, where chemical labels called Methyl groups join DNA, which affects how genes are read and expressed without altering the underlying DNA sequence.
Diet, exercise, stress and smoking are some of the lifestyle factors that can influence DNA methylation, an cornerstone or epigenetics. The extension of methylation varies significant between different types and cell tissues.
“We analyze hundreds of thousands of DNA methylation sites throughout the genome,” Johnson explained.
“He gets a value that tells him how methylated or without methylated is a certain place in his sample,” he added. “Basically, what you get is an exit of a lot of values that the algorithm can translate into an age.”
The results usually arrive within six weeks or the collection of samples.
Why a cheek swab?
Researchers have used everything from blood to saliva to measure biological age: sweat is being tested equally.
Johnson said a cheek swab is as precise as blood collection and more accessible: it can be easily done at home.
“Both types of tissue are quite visual for the prediction of epigenetic age, but an advantage of a cheek swab is only the painless nature of it,” said Johnson.
Tally Health generally recommends testing once or twice a year; Sometimes it has been for months or even a year for an important lifestyle change to be reflected in the results.
How compared to other aging tests
There is no biomarker that definitely reveals how well we are aging, so the trick for consumers is to find the correct measure.
Or the evidence that I have tasks, Tally Health gave me the most optimistic results.
I am 42 years old and I get a count a little less than 37.
Johnson said I am in the upper 5.7% of all users and the higher 3.2% of their classmates.
So I felt quite sure when I accepted to photograph my eyes for an aging test at the Biohackers World Conference last week. I was surprised to be an age or 46.
“If you take 10 different tests of 10 different companies, you will get 10 different results,” Johnson said.
“And the range will be giant. It is likely to be like a range of 20 years in the tests,” he continued. “The reason for that is that companies are using different algorithms, and not all of these tests are optimized for a useful prediction.”
He pointed out that Tally Health’s latest investigation, published in Gerhatcence magazine, showed that his model stood out among the rest for the correlation of the disease.
Hello, he pointed out that the fabrics in different organs, such as those of the cheeks and eyes, in age at different rates.
Popular lifestyle changes
Users are encouraged to carry out a lifestyle survey on their diet, physical conditioning routine, sleep, mental health and daily habits for suggestions on how to reduce their score. My Millennial Millennial lifestyle was considered “moderately healthy”, there is a margin of improvement.
Tallly Health membership ($ 129 per month) includes personalized action plans, every six months, supplements and discounts on products.
“We have seen many people like the challenge of trying to overcome their age,” said Johnson. “It is a child or as gamification in terms of, it is very fun to get a score and optimize it.”
Giving up the already Boaz cigarettes are among the main changes. Johnson said that “Tally Health’s data suggests that any amount of alcohol increases the probability of being greater”, especially 15 or more drinks a week.
What follows Tallly Health?
In his new article, Tally Health linked exposure to PBB-153, a man made by the man used as a flame retardant, with an advanced age. The United States prohibited PBB-153 in the 1970s after it was accidentally mixed in the feeding of animals in Michigan, contaminating the food supply.
“We also saw that people who do not have unreasonable HIV are more likely to be epigenetically older, but when they are treated with antiretrovirals, they are significant, since they are compared to unrelated slurry,” said Johnson.
“These are the son of things that are helping us understand what types of interventions and variables are connected to an older or lesser epigenetic age,” he continued, “and we also identify methylation sites in our model it was.